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Veterans Affairs medical health system identified seven breast cancers Endocrine treatment of transsexual persons: Adults should fulfill the following readiness criteria before the cross-sex hormone treatment. We recommend that adolescents who fulfill eligibility and readiness criteria for gender reassignment initially undergo treatment to suppress pubertal development. But anything less would be less than truthful. Progestin preparations may be an acceptable treatment for persons without access to GnRH analogs or with a needle phobia. The treating clinician must ensure that the desire for transition is appropriate; the consequences, risks, and benefits of treatment are well understood; and the desire for transition persists.
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Hormone Replacement Therapy

In particular breast development can soon become a source of embarrassment for some one still living as a man, it will not shrink significantly when the hormones are stopped, and may eventually require surgical removal gynecomastia. Hormones, a good diet and exercise will radically change a transwoman's body, but a male-type skeleton can't be totally hidden. Sex steroid antagonists via disinhibition of the HPG axis:
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